Paste your panel. See its developability.

sift folds each Fv, maps developability liabilities on both chains, and proposes framework edits that leave the CDRs alone. The result is a report link you can forward to your team.

VHH or paired VH and VL. Up to 100 Fvs per run. Larger panels run as a project, and we set up a call.

Paste

FASTA for VHHs or paired chains.

Read

Liabilities mapped per chain, CDRs left alone.

Forward

A report link your team can open.

WHAT THE REPORT CONTAINS

One row per chain, and the repaired sequence beside the one you sent.

sift_fwr_before / sift_fwr_afterFramework liability load, before and after. This is the pair to read: it is the part sift is allowed to touch.
sift_free_cys_fixAny unpaired cysteine repaired to serine, noted explicitly, including inside CDR3.
sift_n_changedHow many positions moved. Usually a handful, and never in the CDRs unless a free thiol forced it.
sift_germline_shiftHow far the framework moved toward germline.
sift_statusWhy a sequence was left alone, when it was.
sequence_deriskedThe repaired sequence, ready to order.

What it does not measure: binding after repair, expression titer, aggregation or immunogenicity. Those are bench questions, and we run them as a project.